Chronic Rapamycin administration via drinking water mitigates the pathological phenotype in a Krabbe disease mouse model through autophagy activation

: Krabbe disease (KD) is a rare disorder arising from the deficiency of the lysosomal enzyme galactosylceramidase (GALC), leading to the accumulation of the cytotoxic metabolite psychosine (PSY) in the nervous system. This accumulation triggers demyelination and neurodegeneration, and despite ongoing research, the underlying pathogenic mechanisms remain incompletely understood, with no cure currently available. Previous studies from our lab revealed the involvement of autophagy dysfunctions i...

Suppressor of cytokine signaling-3 expression and its regulation in relation to inflammation in Chronic Obstructive Pulmonary Disease

Background: The family of Suppressor of Cytokine Signaling (SOCS) acts as a controller of the duration and intensity of cytokine function by negatively regulating the JAK-STAT signaling pathway. SOCS' role in inflammatory diseases in animal models is well demonstrated. However, its role in the development of human disease is still under investigation. SOCS3 plays an important role in tumor development where its downregulation has been implicated in the pathogenesis of various solid tumors suc...

A Flower never Blossomed: the Overshadowed Silhouette of Privacy in the Realm of the English Law of Tort

Emotional Intelligence and Social Media Use: Dissociative Experiences and Fear of Missing Out as Mediators

The increasing prevalence of social media usage has sparked a growing interest in understanding the factors contributing to problematic social media use (PSMU). This study explores this phenomenon through the lens of the Interaction Person-Affect-Cognition-Execution (I-PACE) model. Specifically, it investigates whether the fear of missing out (FoMO) and dissociative experiences (DE) serve as sequential mediators in the relationship between trait emotional intelligence (trait EI) and PSMU, and...