Background: Sequence requirements for triple-helical collagen to bind fibronectin are not fully understood. Results: Fibronectin affinity was conferred on a recombinant bacterial collagen by incorporating specific human collagen II sequences. Conclusion: The chimeric collagen defines the minimum collagen II sequence required for fibronectin affinity. Significance: This system is useful to investigate sequence/activity relationships for triple-helical collagen and to generate scalable bioactive materials. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.
Definition of the native and denatured type II collagen binding site for fibronectin using a recombinant collagen system
Abbonante V.;
2014-01-01
Abstract
Background: Sequence requirements for triple-helical collagen to bind fibronectin are not fully understood. Results: Fibronectin affinity was conferred on a recombinant bacterial collagen by incorporating specific human collagen II sequences. Conclusion: The chimeric collagen defines the minimum collagen II sequence required for fibronectin affinity. Significance: This system is useful to investigate sequence/activity relationships for triple-helical collagen and to generate scalable bioactive materials. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.File in questo prodotto:
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