The insulin receptor is a cell surface glycoprotein that mediates the action of insulin on target cells. The receptor was originally identified by its ability to bind the hormone (Freychet et al., l97la, b; Cuatrecasas, 1971). Over the past two decades considerable progress has been made in defining the structure of the receptor molecule (Kahn et al., 1981; Ullrich et al., 1985; Ebina et al., 1985; Taylor, 1988) as well as the biochemical mechanism by which it mediates insulin action (Kasuga et al., 1982a, b; Rosen, 1987).
Mutations in the insulin receptor gene in genetic forms of insulin resistance
PERROTTI N;
1990-01-01
Abstract
The insulin receptor is a cell surface glycoprotein that mediates the action of insulin on target cells. The receptor was originally identified by its ability to bind the hormone (Freychet et al., l97la, b; Cuatrecasas, 1971). Over the past two decades considerable progress has been made in defining the structure of the receptor molecule (Kahn et al., 1981; Ullrich et al., 1985; Ebina et al., 1985; Taylor, 1988) as well as the biochemical mechanism by which it mediates insulin action (Kasuga et al., 1982a, b; Rosen, 1987).File in questo prodotto:
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