The insulin receptor is a cell surface glycoprotein that mediates the action of insulin on target cells. The receptor was originally identiﬁed by its ability to bind the hormone (Freychet et al., l97la, b; Cuatrecasas, 1971). Over the past two decades considerable progress has been made in deﬁning the structure of the receptor molecule (Kahn et al., 1981; Ullrich et al., 1985; Ebina et al., 1985; Taylor, 1988) as well as the biochemical mechanism by which it mediates insulin action (Kasuga et al., 1982a, b; Rosen, 1987).
|Titolo:||Mutations in the insulin receptor gene in genetic forms of insulin resistance|
|Data di pubblicazione:||1990|
|Appare nelle tipologie:||1.1 Articolo in rivista|