A series of N-substituted-3-[(2′-hydroxy-4′-prenyloxy)-phenyl]- 5-phenyl-4,5-dihydro-(1H)-pyrazolines were synthesized and tested on human monoamine oxidase-A and -B isoforms. Structure-activity relationships and molecular modelling showed that some substitutions, such as benzyloxy or chlorine atom, improve the best interaction with active site of hMAO-B
Synthesis and molecular modelling studies of prenylated pyrazolines as MAO-B inhibitors
Alcaro S;ORTUSO F
2010-01-01
Abstract
A series of N-substituted-3-[(2′-hydroxy-4′-prenyloxy)-phenyl]- 5-phenyl-4,5-dihydro-(1H)-pyrazolines were synthesized and tested on human monoamine oxidase-A and -B isoforms. Structure-activity relationships and molecular modelling showed that some substitutions, such as benzyloxy or chlorine atom, improve the best interaction with active site of hMAO-BFile in questo prodotto:
Non ci sono file associati a questo prodotto.
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
