Behavioural and electrocortical spectrum power changes after intraventricular injection of patulin in rats.

The effects of patulin when given into the third cerebral ventricle of rats, on behaviour and electrocortical spectrum power have been investigated. Patulin (10 micrograms i.v.t.) produced behavioural sedation, hypoalgesia, tail rigidity, piloerection and postural changes. This symptomatology lasted approx. 3 h and was accompanied by slower frequency and larger amplitude potentials in the electrocorticogram (ECoG) and by an increase in total voltage power. A larger dose (50 micrograms) produced a more dramatic picture characterized by catatonic posture with kyphosis, loss of the righting reflex, tail rigidity and on a few occasions short-duration episodes of tonic-clonic convulsions. Such a symptomatology was accompanied by a flattening of ECoG activity with a significant fall in total voltage power, as well as in preselected bands (0-3, 3-6, 6-9, 9-12, and 12-16 Hz). A lower dose (1 microgram) of patulin, on the other hand, produced behavioural sedation without significant changes in ECoG spectrum power.