Desipramine (10 mg/kg, i.p.), a specific blocker of noradrenaline uptake, significantly antagonized the decrease of brain noradrenaline induced by an intraventricular injection of 6-hydroxydopamine (200 micrograms in 20 microliter) in rats. The depletion of brain dopamine, in 6-hydroxydopamine plus pargyline-treated rats was counteracted by nomifensine (10 mg/kg, i.p.), a drug which has been reported to markedly inhibit dopamine uptake both in vivo and in vitro. Carbamazepine (10 mg/kg, i.p.), phenytoin (200 mg/kg, orally) and phenobarbital (20 mg/kg, orally) were unable to significantly affect either the decrease of noradrenaline or the depletion of dopamine induced by 6-hydroxydopamine. These findings seem to suggest that these anticonvulsant drugs do not inhibit brain catecholamine uptake in vivo in male rats.
Carbamazepine, phenytoin and phenobarbital do not influence brain catecholamine uptake, in vivo, in male rats.
Aguglia U;
1981-01-01
Abstract
Desipramine (10 mg/kg, i.p.), a specific blocker of noradrenaline uptake, significantly antagonized the decrease of brain noradrenaline induced by an intraventricular injection of 6-hydroxydopamine (200 micrograms in 20 microliter) in rats. The depletion of brain dopamine, in 6-hydroxydopamine plus pargyline-treated rats was counteracted by nomifensine (10 mg/kg, i.p.), a drug which has been reported to markedly inhibit dopamine uptake both in vivo and in vitro. Carbamazepine (10 mg/kg, i.p.), phenytoin (200 mg/kg, orally) and phenobarbital (20 mg/kg, orally) were unable to significantly affect either the decrease of noradrenaline or the depletion of dopamine induced by 6-hydroxydopamine. These findings seem to suggest that these anticonvulsant drugs do not inhibit brain catecholamine uptake in vivo in male rats.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.