A set of novel 1-aryl-6,7-methylenedioxy-3H-quinazolin-4-(thi)ones (3a-f) has been designed and screened as anticonvulsant agents in DBA/2 mice. The new compounds are provided with anticonvulsant properties comparable to those of GYKI 52466. To clarify the mode of action, their affinity for the quinazolinone/2,3-benzodiazepine site of the AMPA receptor complex has been assayed. (C) 2003 Elsevier Ltd. All rights reserved.
Titolo: | 1-Aryl-6,7-methylenedioxy-3H-quinazolin-4-ones as anticonvulsant agents |
Autori: | |
Data di pubblicazione: | 2003 |
Rivista: | |
Abstract: | A set of novel 1-aryl-6,7-methylenedioxy-3H-quinazolin-4-(thi)ones (3a-f) has been designed and screened as anticonvulsant agents in DBA/2 mice. The new compounds are provided with anticonvulsant properties comparable to those of GYKI 52466. To clarify the mode of action, their affinity for the quinazolinone/2,3-benzodiazepine site of the AMPA receptor complex has been assayed. (C) 2003 Elsevier Ltd. All rights reserved. |
Handle: | http://hdl.handle.net/20.500.12317/15039 |
Appare nelle tipologie: | 1.1 Articolo in rivista |
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