Identification of a Btk-BAG3 complex induced by oxidative stress

Bruton’s tyrosine kinase (Btk), which is important in B-cell development and activation, is a member of the Btk/Tec family of cytoplasmic tyrosine kinases, sharing a pleckstrin homology domain and Src homology SH3 and SH2 domains.1,2 Btk has vital, but diverse, regulatory activities in various cellular processes. Among cell programs regulated by Btk there is apoptosis that can be either stimulated or inhibited by the kinase in different contexts.1–3 The identification of molecular partners that can interact with Btk is required to individuate elements and understand mechanisms that regulate the kinase activity.