Purpose: To determine the significant correlations between retinal sensitivity measured by fundus-related microperimetry and the visual acuity and the foveal thickness measured by optical coherence tomography (OCT) in eyes with Diabetic Macular Edema (DME) during diurnal variations of blood glucose levels. Methods: 30 eyes with macular edema of 40 consecutive patients with type1 diabete and 20 eyes of 20 normal subjects were included in our study. Best corrected visual acuity (ETDRS charts), macular thickness, macular sensitivity, and blood glucose concentration were quantified in all patients twice a day (10 am, 5 pm). Optical coherence tomography (Stratus OCT, Zeiss) was used to quantify macular thickness; macular sensitivity and retinal fixation were evaluated with fundus related microperimeter (MP1,Nidek). Results: The mean sensitivities in examinated area were significantly lower in patients with DME than in normal subjects (P<0.0001). The mean retinal sensitivities were inversely correlated with visual acuity and foveal thickness, in according with glucose plasmatic level. ). Conclusions: The mean retinal sensitivities measured with fundus-related microperimetry were significantly lower in eyes with DME than in normal eyes. A significant correlation between the microperimeter-determined retinal sensitivity and visual acuity and foveal thickness was observed in the course of the day compared to blood glucose level. MP1 and OCT could be useful techniques in morphological and functional macular analyses of DME.
|Titolo:||Morphological and functional analyses of diabetic macular edema in diurnal fluctuation by optical coherence tomography and fundus related microperimetry in patients with type 1 diabetes|
|Data di pubblicazione:||2007|
|Appare nelle tipologie:||1.5 Abstract in rivista|