Full field ERG values before and after anti-VEFG treatment in AMD affected subjects

Purpose: To compare ERG b-wave amplitude differences before and after treatment with sodium pegaptanib intra-vitreal injection. Methods: 14 patients all affected by exudative AMD were submitted to scotopic, combined and fotopic full field ERG, to estimate photoreceptorial electric activity through b-wave amplitude. All patients have then been treated with 1 to 4 intravitreal injections of 0,3 ml sodium pegaptanib. Time between each injection was 2-4 weeks. After one and two months than first injection all patients were again submitted to full field ERG. Data were related with ERGs obtained before first injection. Results: In 6 patients we found a b-wave amplitude increase of about 20% two months after first injection. Remaining 8 patients showed no valuable differences in ERG amplitude before and after treatment. Conclusions: In a valuable number of subjects, sodium pegaptanib intravitreal injection, seem to emprove photoreceptorial electric activity. Other studies are needed to confirm this hypothesis.