Limbic encephalitis (LE) can be a paraneoplastic or idiopathic autoimmune disorder. The classic onset is subacute and is characterized by temporal seizures, memory deficits and personality disorders. MRI of the brain on T2-weighted FLAIR classically shows hyperintensities of the mesiotemporal structures, but multifocal involvement of extratemporal cortex has also been described in paraneoplastic LE. Here we describe a 27-year-old woman whose idiopathic autoimmune (GAD-Ab positive) LE was associated with mesio-temporal seizures and multifocal extratemporal cortical MRI abnormalities, without the classical mesiotemporal lobe involvement.
Neocortical extratemporal lesions and temporal seizures heralding limbic encephalitis: A case report
Aguglia U
2010-01-01
Abstract
Limbic encephalitis (LE) can be a paraneoplastic or idiopathic autoimmune disorder. The classic onset is subacute and is characterized by temporal seizures, memory deficits and personality disorders. MRI of the brain on T2-weighted FLAIR classically shows hyperintensities of the mesiotemporal structures, but multifocal involvement of extratemporal cortex has also been described in paraneoplastic LE. Here we describe a 27-year-old woman whose idiopathic autoimmune (GAD-Ab positive) LE was associated with mesio-temporal seizures and multifocal extratemporal cortical MRI abnormalities, without the classical mesiotemporal lobe involvement.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
