In vivo melatonin treatment significantly reduced, in dose-dependent manner, peroxynitrite formation and prevented the PARS activation in macrophages collected from rats subjected to carrageenan-induced pleurisy. Our study support the view that the antioxidant and anti-inflammatoy effect of melatonin is also correlated with the inhibition of peroxynitrite production and PARS activation.
Effect of melatonin on cellular injury in an acute model of inflammation
BRITTI D
Investigation
;
2000-01-01
Abstract
In vivo melatonin treatment significantly reduced, in dose-dependent manner, peroxynitrite formation and prevented the PARS activation in macrophages collected from rats subjected to carrageenan-induced pleurisy. Our study support the view that the antioxidant and anti-inflammatoy effect of melatonin is also correlated with the inhibition of peroxynitrite production and PARS activation.File in questo prodotto:
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