Aim of the present study was to evaluate the potential beneficial and/or adverseeffects of Capsicum annuumL. (cv. Fiesta) extracts at two stage of ripening(immature and mature), and at two dosages (low and high) by evaluation ofbiochemical profile and oxidative status in CD-1 mice. The extracts were dailyadministered to mice by oral gavage for 20 days. At the end of the trial, theanimals were euthanatized and blood was collected. Evidence of liver damage(increase of AST, ALT, ALP and bilirubin) in the group receiving the higherdosage of immature peppers extract. Even if no adverse effects were seen at thelower doses, also no signs of beneficial effects in term of health status,biochemical profile and oxidative status were detected. These results are incontrast with in vitro findings and raise doubts about the possible use ofCapsicum annuum L. as a nutritional supplement.
Potential beneficial and/or adverse effects of Capsicum annuum L. (cv. Fiesta) at two stage of ripening in CD-1 mice
Morittu V;Britti D;
2020-01-01
Abstract
Aim of the present study was to evaluate the potential beneficial and/or adverseeffects of Capsicum annuumL. (cv. Fiesta) extracts at two stage of ripening(immature and mature), and at two dosages (low and high) by evaluation ofbiochemical profile and oxidative status in CD-1 mice. The extracts were dailyadministered to mice by oral gavage for 20 days. At the end of the trial, theanimals were euthanatized and blood was collected. Evidence of liver damage(increase of AST, ALT, ALP and bilirubin) in the group receiving the higherdosage of immature peppers extract. Even if no adverse effects were seen at thelower doses, also no signs of beneficial effects in term of health status,biochemical profile and oxidative status were detected. These results are incontrast with in vitro findings and raise doubts about the possible use ofCapsicum annuum L. as a nutritional supplement.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
