Preparations of two new β-adrenergic blocking drugs, Zami 1305 [1-(2-nitro-3-methyl-phenoxy) -3-tert-butylaminopropan-2-ol] and Zami 1327 [1-(6-nitro-3-methyl-phenoxy) -3-tert-butylaminopropan-2-ol], were found to be contaminated by epoxides which are direct acting mutagens on TA 100 and TA 1535 in the Salmonella/microsome mutagenicity test. Because of the suggested correlation between mutagenicity and carcinogenicity of a chemical [10,11], β-adrenergic blocking agents contaminated by mutagenic epoxide impurities may be a health hazard.
|Titolo:||Mutagenic epoxide impurities discovered in two beta-adrenergic blocking agents|
|Data di pubblicazione:||1980|
|Appare nelle tipologie:||1.1 Articolo in rivista|