Interleukin-1, interleukin-2 and interleukin-3 injected into the third cerebral ventricle produce typical behavioural sedation and/or sleep and ECoG synchronization in rats. Much smaller doses were required to produce similar behavioural and ECoG spectrum power effects after infusion of interleukins into the locus coeruleus. Interleukin-1 and interleukin-3 induced pyrogenic effects while interleukin-2 produced no pyrogenic actions. These effects were blocked by specific anti-interleukin receptors monoclonal antibodies. In addition, naloxone was able to antagonize the central effects of IL-2 but it did not affect the typical changes induced by IL-1. These results are consistent with the hypothesis that the behavioural, body temperature and ECoG changes of these lymphokines are mediated by specific receptors.
Behavioural, electrocortical spectrum power and body temperature changes after microinfusion of some lymphokines in the rat brain.
De Sarro G;
1991-01-01
Abstract
Interleukin-1, interleukin-2 and interleukin-3 injected into the third cerebral ventricle produce typical behavioural sedation and/or sleep and ECoG synchronization in rats. Much smaller doses were required to produce similar behavioural and ECoG spectrum power effects after infusion of interleukins into the locus coeruleus. Interleukin-1 and interleukin-3 induced pyrogenic effects while interleukin-2 produced no pyrogenic actions. These effects were blocked by specific anti-interleukin receptors monoclonal antibodies. In addition, naloxone was able to antagonize the central effects of IL-2 but it did not affect the typical changes induced by IL-1. These results are consistent with the hypothesis that the behavioural, body temperature and ECoG changes of these lymphokines are mediated by specific receptors.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
