GREEN METHODOLOGIES IN ORGANIC SYNTHESIS FOR THE PREPARATION OF BIOACTIVE MOLECULES

In the last decades, organic chemistry is undergoing a green revolution in order to avoid waste by developing a cleaner and safer chemistry in the chemical and pharmaceutical industry. One of the main objectives of organic synthesis is to design molecules with high added value by developing highly selective, economical and environmentally friendly synthetic procedures. To satisfy these expectation new methods must be developed in order to shorten the synthesis, to avoid pollutants or toxic organic solvents and to respect the principle of atom economy. In addition, the selection of mild reaction conditions for the use of protective groups is a crucial seek of the contemporary synthetic chemistry. In this context, we explored the applicability of ionic liquids (ILs) and deep eutectic solvents (DES) green solvents as reaction media, for the selective introduction and removal of various protecting groups and for the synthesis of potential biologically active compounds developing new environmentally friendly procedures.