In this paper a new catalyst-free and on-water method for protection of amines and amino acids with ditert- butyl dicarbonate, 9-fluorenylmethoxycarbonyl chloride, acetyl chloride and tosyl chloride is presented. The protection can be realized in a few minutes under microwave-assistance. The reaction proved to be chemoselective in presence of ambident nucleophiles and water solution of di-tert-butyl carboxylic acid or chloride acid are the only wastes produced.

Aqueous MW eco-friendly protocol for amino group protection

Nardi M;Procopio A;Oliverio M
2015-01-01

Abstract

In this paper a new catalyst-free and on-water method for protection of amines and amino acids with ditert- butyl dicarbonate, 9-fluorenylmethoxycarbonyl chloride, acetyl chloride and tosyl chloride is presented. The protection can be realized in a few minutes under microwave-assistance. The reaction proved to be chemoselective in presence of ambident nucleophiles and water solution of di-tert-butyl carboxylic acid or chloride acid are the only wastes produced.
2015
MW-assisted reaction; protection of amines; protection of amino acids
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.12317/5840
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