In this paper a new catalyst-free and on-water method for protection of amines and amino acids with ditert- butyl dicarbonate, 9-fluorenylmethoxycarbonyl chloride, acetyl chloride and tosyl chloride is presented. The protection can be realized in a few minutes under microwave-assistance. The reaction proved to be chemoselective in presence of ambident nucleophiles and water solution of di-tert-butyl carboxylic acid or chloride acid are the only wastes produced.
|Titolo:||Aqueous MW eco-friendly protocol for amino group protection|
|Data di pubblicazione:||2015|
|Appare nelle tipologie:||1.1 Articolo in rivista|