In this paper a new catalyst-free and on-water method for protection of amines and amino acids with ditert- butyl dicarbonate, 9-fluorenylmethoxycarbonyl chloride, acetyl chloride and tosyl chloride is presented. The protection can be realized in a few minutes under microwave-assistance. The reaction proved to be chemoselective in presence of ambident nucleophiles and water solution of di-tert-butyl carboxylic acid or chloride acid are the only wastes produced.
Titolo: | Aqueous MW eco-friendly protocol for amino group protection |
Autori: | |
Data di pubblicazione: | 2015 |
Rivista: | |
Handle: | http://hdl.handle.net/20.500.12317/5840 |
Appare nelle tipologie: | 1.1 Articolo in rivista |
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