Efficient one-pot three component reaction of aniline derivatives with cyanoamide and triethyl orthoformate at reflux in toluene affords N0-aryl-N-cyanoformamidines in high yields just by the distillation of the azeotrope toluene/ethyl alcohol. Labelled d9-Amitraz is prepared by the application of this procedure in the synthesis of formamidine pesticides family.
|Titolo:||Development of one-pot three component reaction for the synthesis of N’-aryl-N cyanoformamidines, essential precursors of formamidine pesticides family|
|Data di pubblicazione:||2016|
|Appare nelle tipologie:||1.1 Articolo in rivista|