The complete set of the 4-'aza analogues of 2',3'-dideoxynucleosides was synthesized by cycloaddition of N-tetrahydropiranyl or N-trityl methylene nitrones on suitably protected vinyl nucleobases. The convertible nucleoside approach was used in the preparation of cytosine and 5-methyl cytosine analogues.

Synthesis of isoxazolidino analogues of 2',3'-dideoxynucleosides

De Nino A.;Procopio A.;Sindona G.
1999-01-01

Abstract

The complete set of the 4-'aza analogues of 2',3'-dideoxynucleosides was synthesized by cycloaddition of N-tetrahydropiranyl or N-trityl methylene nitrones on suitably protected vinyl nucleobases. The convertible nucleoside approach was used in the preparation of cytosine and 5-methyl cytosine analogues.
1999
Dideoxynucleosides; Magnetic Resonance Spectroscopy; Nucleic Acid Conformation; Oxazoles; Spectrometry, Mass, Fast Atom Bombardment
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.12317/59239
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