We prospectively evaluated the prognostic significance of forearm endothelial dysfunction in 225 initially untreated hypertensive patients without previous complications. Intraarterial acetylcholine infusions caused a dose-dependent and significant increase in forearm blood flow and a decrease in forearm vascular resistance. The risk of cardiac events was lowest in patients with the largest increase in forearm blood flow. Our results suggest acetylcholine-stimulated forearm blood flow may help to define the benefit of antihypertensive treatment and to assess the time course of atherosclerosis and its clinical consequences.
Endothelial dysfunction in hypertensive patients
Pujia A.;Perticone F.
2002-01-01
Abstract
We prospectively evaluated the prognostic significance of forearm endothelial dysfunction in 225 initially untreated hypertensive patients without previous complications. Intraarterial acetylcholine infusions caused a dose-dependent and significant increase in forearm blood flow and a decrease in forearm vascular resistance. The risk of cardiac events was lowest in patients with the largest increase in forearm blood flow. Our results suggest acetylcholine-stimulated forearm blood flow may help to define the benefit of antihypertensive treatment and to assess the time course of atherosclerosis and its clinical consequences.File in questo prodotto:
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