The exchange of solutes between the blood and the nerve tissue is mediated by specific and high selective barriers in order to ensure the integrity of the di erent compartments of the nervous system. At peripheral level, this function is maintained by the Blood Nerve Barrier (BNB) that, in the presence, of specific stressor stimuli can be damaged causing the onset of neurodegenerative processes. An essential component of BNB is represented by the endothelial cells surrounding the sub-structures of peripheral nerves and increasing evidence suggests that endothelial dysfunction can be considered a leading cause of the nerve degeneration. The purpose of this review is to highlight the main mechanisms involved in the impairment of endothelial cells in specific diseases associated with peripheral nerve damage, such as diabetic neuropathy, erectile dysfunction and inflammation of the sciatic nerve.

The role of endothelial dysfunction in peripheral blood nerve barrier: Molecular mechanisms and pathophysiological implications

Maiuolo J.;Gliozzi M.;Musolino V.;Carresi C.;Macri R.;Bosco F.;Scarano F.;Ruga S.;Zito M. C.;Oppedisano F.;Palma E.;Muscoli C.;Mollace V.
2019-01-01

Abstract

The exchange of solutes between the blood and the nerve tissue is mediated by specific and high selective barriers in order to ensure the integrity of the di erent compartments of the nervous system. At peripheral level, this function is maintained by the Blood Nerve Barrier (BNB) that, in the presence, of specific stressor stimuli can be damaged causing the onset of neurodegenerative processes. An essential component of BNB is represented by the endothelial cells surrounding the sub-structures of peripheral nerves and increasing evidence suggests that endothelial dysfunction can be considered a leading cause of the nerve degeneration. The purpose of this review is to highlight the main mechanisms involved in the impairment of endothelial cells in specific diseases associated with peripheral nerve damage, such as diabetic neuropathy, erectile dysfunction and inflammation of the sciatic nerve.
2019
Blood Nerve Barrier (BNB); Diabetic neuropathy; Endothelial dysfunction; Erectile dysfunction; Neuropathic pain; Nitric oxide; Nitric oxide synthase (NOS); Peripheral nerve injury; Animals; Blood-Nerve Barrier; Diabetic Neuropathies; Endothelium; Erectile Dysfunction; Humans; Male; Neuralgia; Nitric Oxide; Nitric Oxide Synthase; Peripheral Nerve Injuries
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.12317/61649
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