Reviewing the histopathologic findings of a series of 518 radical nephrectomies, small cell carcinomas of the kidney were identified in 4 patients, 2 men and 2 women, ranging in age between 35 and 68 years. Immunohistochemical studies were performed using monoclonal antibodies against Chromogranin A and Cytokeratin with ABC procedure, and they revealed positivity for chromogranin A in the majority of the cells in one case, supporting the neuroendocrine lineage of these tumors, presumably originating from a totipotential stem cell. Clinically these neoplasms were uniformly of high stage at presentation and aggressive, since all patients died within 16 months of surgery.
Small cell carcinoma of the kidney: Description of four new cases with immunohistochemical evaluation
Amorosi A.;
1993-01-01
Abstract
Reviewing the histopathologic findings of a series of 518 radical nephrectomies, small cell carcinomas of the kidney were identified in 4 patients, 2 men and 2 women, ranging in age between 35 and 68 years. Immunohistochemical studies were performed using monoclonal antibodies against Chromogranin A and Cytokeratin with ABC procedure, and they revealed positivity for chromogranin A in the majority of the cells in one case, supporting the neuroendocrine lineage of these tumors, presumably originating from a totipotential stem cell. Clinically these neoplasms were uniformly of high stage at presentation and aggressive, since all patients died within 16 months of surgery.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
