Between November 1985 and December 1991, 246 consecutive patients with gastric cancer were operated on at our clinic. Resection of the tumors included lymphadenectomy of compartment I. The resectability rate was 74%, the operative mortality 1.2%. Follow-up data were available for all the 173 resected patients and the overall 5-year survival rate according to the method of Kaplan-Meier was 35%. The median survival rate in the deceased patients was 12 mths (range 2-52) whereas the median follow-up in patients still alive was 56 mths (range 24 months-8 years). A univariate and a multivariate analysis by the proportional hazard model (Cox regression analysis) identified vascular invasion, grading and number of positive lymph nodes (in addition to tumour stage and age) as the most significant prognostic parameters. Our results emphasize safety and efficacy of surgery without any adjuvant therapy in the treatment of gastric cancer, and seem to suggest a changing clinical behaviour of this tumour that needs further confirmation from ploidy and cellular kinetic studies.
Surgery of gastric neoplasms. Results and statistical analysis of prognostic factors
Amorosi A.;
1997-01-01
Abstract
Between November 1985 and December 1991, 246 consecutive patients with gastric cancer were operated on at our clinic. Resection of the tumors included lymphadenectomy of compartment I. The resectability rate was 74%, the operative mortality 1.2%. Follow-up data were available for all the 173 resected patients and the overall 5-year survival rate according to the method of Kaplan-Meier was 35%. The median survival rate in the deceased patients was 12 mths (range 2-52) whereas the median follow-up in patients still alive was 56 mths (range 24 months-8 years). A univariate and a multivariate analysis by the proportional hazard model (Cox regression analysis) identified vascular invasion, grading and number of positive lymph nodes (in addition to tumour stage and age) as the most significant prognostic parameters. Our results emphasize safety and efficacy of surgery without any adjuvant therapy in the treatment of gastric cancer, and seem to suggest a changing clinical behaviour of this tumour that needs further confirmation from ploidy and cellular kinetic studies.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
