We have studied the phenomenon of vesicle fusion by differential scanning calorimetric (DSC) and scanning dilatometric (SD) measurements of pure and mixed phospholipids containing CDP-choline. In our study on mixed phospholipid systems, two preparation methods for multilamellar vesicles were used: homogeneous and heterogeneous. The fusion, characteristic of the charged system, is inhibited in the presence of the drug, but occurs when dipalmitoylphosphatidylserine (DPPS) was "diluted" in dipalmitoylphosphatidylcholine (DPPC). In addition, we have evaluated the inclusion efficiency in pure and mixed phospholipids, finding that DPPC/DPPS (3:1 molar ratio) liposomes are the best "hostguest" system, considering the fusion properties and the inclusion efficiency. © 1992.
Phospholipid vesicles as drug delivery systems. Part II. A study on kinetic fusion between vesicles containing CDP-choline and dipalmitoylphosphatidylcholine vesicles
Fresta M.;
1992-01-01
Abstract
We have studied the phenomenon of vesicle fusion by differential scanning calorimetric (DSC) and scanning dilatometric (SD) measurements of pure and mixed phospholipids containing CDP-choline. In our study on mixed phospholipid systems, two preparation methods for multilamellar vesicles were used: homogeneous and heterogeneous. The fusion, characteristic of the charged system, is inhibited in the presence of the drug, but occurs when dipalmitoylphosphatidylserine (DPPS) was "diluted" in dipalmitoylphosphatidylcholine (DPPC). In addition, we have evaluated the inclusion efficiency in pure and mixed phospholipids, finding that DPPC/DPPS (3:1 molar ratio) liposomes are the best "hostguest" system, considering the fusion properties and the inclusion efficiency. © 1992.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
