The inclusion complex of Idebenone (IDE) in β-cyclodextrin (β-CD) was prepared by means of two different methods (coprecipitation and freeze-drying). The obtained IDE-β-CD complex was characterized at the solid state by differential scanning calorimetry (DSC) and X-ray diffractometry. UV, CD and 1H-NMR spectroscopies were carried out to study the complex in solution. Solubility studies of IDE in the presence of β-CD have shown a linear increase in drug solubility. The enhancement of dissolution rate of IDE-β-CD complex with respect to free drug is significant, particularly for freeze-dried complex.

Solid state characterization and in solution studies of idebenone-β-cyclodextrin inclusion complex

Fresta M.;
1995-01-01

Abstract

The inclusion complex of Idebenone (IDE) in β-cyclodextrin (β-CD) was prepared by means of two different methods (coprecipitation and freeze-drying). The obtained IDE-β-CD complex was characterized at the solid state by differential scanning calorimetry (DSC) and X-ray diffractometry. UV, CD and 1H-NMR spectroscopies were carried out to study the complex in solution. Solubility studies of IDE in the presence of β-CD have shown a linear increase in drug solubility. The enhancement of dissolution rate of IDE-β-CD complex with respect to free drug is significant, particularly for freeze-dried complex.
1995
β-cyclodextrin
dissolution rate
Idebenone
solubility studies
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.12317/63718
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