The inclusion complex of Idebenone (IDE) in β-cyclodextrin (β-CD) was prepared by means of two different methods (coprecipitation and freeze-drying). The obtained IDE-β-CD complex was characterized at the solid state by differential scanning calorimetry (DSC) and X-ray diffractometry. UV, CD and 1H-NMR spectroscopies were carried out to study the complex in solution. Solubility studies of IDE in the presence of β-CD have shown a linear increase in drug solubility. The enhancement of dissolution rate of IDE-β-CD complex with respect to free drug is significant, particularly for freeze-dried complex.
Solid state characterization and in solution studies of idebenone-β-cyclodextrin inclusion complex
Fresta M.;
1995-01-01
Abstract
The inclusion complex of Idebenone (IDE) in β-cyclodextrin (β-CD) was prepared by means of two different methods (coprecipitation and freeze-drying). The obtained IDE-β-CD complex was characterized at the solid state by differential scanning calorimetry (DSC) and X-ray diffractometry. UV, CD and 1H-NMR spectroscopies were carried out to study the complex in solution. Solubility studies of IDE in the presence of β-CD have shown a linear increase in drug solubility. The enhancement of dissolution rate of IDE-β-CD complex with respect to free drug is significant, particularly for freeze-dried complex.File in questo prodotto:
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