Charged (dipalmitoylphosphatidylserine (DPPS) and dipalmitoylphosphatidic acid (DPPA) and zwitterionic (dipalmitoylphosphatidylethanolamine (DPPE) and dipalmitoylphosphatidylcholine (DPPC) phospholipid vesicles were used as a drug delivery device containing cytidine-5'-diphosphate choline (CDP-choline). To evaluate the interaction between the membrane surface and CDP-choline, the thermodynamic behaviour, linked with gel-liquid crystal phase transition was analyzed by differential scanning calorimetry (DSC) and scanning dilatometry (SD). Analysis of thermodynamic parameters shows that the interaction between CDP-choline and phospholipid heads is very weak for DPPC, but is strong for DPPE and DPPA systems; DPPS interacts very strongly with CDP-choline so is not able to form liposomes. © 1992.
Phospholipid vesicles as a drug delivery system. Part I. Interaction of cytidine-5'-diphosphate choline with charged and zwitterionic phospholipids
Fresta M.;
1992-01-01
Abstract
Charged (dipalmitoylphosphatidylserine (DPPS) and dipalmitoylphosphatidic acid (DPPA) and zwitterionic (dipalmitoylphosphatidylethanolamine (DPPE) and dipalmitoylphosphatidylcholine (DPPC) phospholipid vesicles were used as a drug delivery device containing cytidine-5'-diphosphate choline (CDP-choline). To evaluate the interaction between the membrane surface and CDP-choline, the thermodynamic behaviour, linked with gel-liquid crystal phase transition was analyzed by differential scanning calorimetry (DSC) and scanning dilatometry (SD). Analysis of thermodynamic parameters shows that the interaction between CDP-choline and phospholipid heads is very weak for DPPC, but is strong for DPPE and DPPA systems; DPPS interacts very strongly with CDP-choline so is not able to form liposomes. © 1992.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
