In the present study we have investigated whether pharmacological manipulations of central l-arginine-nitric oxide (l-Arg-NO) pathway could affect blood pressure (BP) and heart rate (HR) in normotensive rats either untreated or pretreated with E. coli lipopolysaccharide (LPS). The intracerebroventricular injection (i.c.v.) of Nω-nitro-l-arginine methyl ester (l-NAME), an inhibitor of NO synthesis, caused a fall of BP and HR in LPS-treated but not in control rats. Furthermore, the pressor responses to i.c.v. injection of N-methyl-d-aspartate (NMDA) were enhanced by l-Arg or LPS treatment and, in both cases, this potentiation was blocked by l-NAME. The present results show that in some experimental conditions, such as activation of NMDA receptors or LPS pretreatment, the central microinfusion of drugs affecting the l-Arg-NO pathway may interfere with BP and HR. © 1992.

Evidence that pharmacological manipulations of central l-arginine-NO pathway influence blood pressure and heart rate in rats

Mollace V.;
1992-01-01

Abstract

In the present study we have investigated whether pharmacological manipulations of central l-arginine-nitric oxide (l-Arg-NO) pathway could affect blood pressure (BP) and heart rate (HR) in normotensive rats either untreated or pretreated with E. coli lipopolysaccharide (LPS). The intracerebroventricular injection (i.c.v.) of Nω-nitro-l-arginine methyl ester (l-NAME), an inhibitor of NO synthesis, caused a fall of BP and HR in LPS-treated but not in control rats. Furthermore, the pressor responses to i.c.v. injection of N-methyl-d-aspartate (NMDA) were enhanced by l-Arg or LPS treatment and, in both cases, this potentiation was blocked by l-NAME. The present results show that in some experimental conditions, such as activation of NMDA receptors or LPS pretreatment, the central microinfusion of drugs affecting the l-Arg-NO pathway may interfere with BP and HR. © 1992.
1992
Brain
Cardiovascular regulation
Nitric Oxide
NMDA
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.12317/63756
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 21
  • ???jsp.display-item.citation.isi??? ND
social impact