The one-pot reduction of α-alkyl-β-ketonitriles to anti γ-amino alcohols can be efficiently performed by borane/dimethyl sulfide complex in the presence of cerium chloride as Lewis acid. Selectivities are slightly worse than monoreduction but this drawback is overcome by much better yields. © Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002.
Stereoselective complete reduction of α-alkyl-β-ketonitriles to anti γ-amino alcohols
Procopio A.;
2002-01-01
Abstract
The one-pot reduction of α-alkyl-β-ketonitriles to anti γ-amino alcohols can be efficiently performed by borane/dimethyl sulfide complex in the presence of cerium chloride as Lewis acid. Selectivities are slightly worse than monoreduction but this drawback is overcome by much better yields. © Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002.File in questo prodotto:
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