The one-pot reduction of α-alkyl-β-ketonitriles to anti γ-amino alcohols can be efficiently performed by borane/dimethyl sulfide complex in the presence of cerium chloride as Lewis acid. Selectivities are slightly worse than monoreduction but this drawback is overcome by much better yields. © Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002.

Stereoselective complete reduction of α-alkyl-β-ketonitriles to anti γ-amino alcohols

Procopio A.;
2002-01-01

Abstract

The one-pot reduction of α-alkyl-β-ketonitriles to anti γ-amino alcohols can be efficiently performed by borane/dimethyl sulfide complex in the presence of cerium chloride as Lewis acid. Selectivities are slightly worse than monoreduction but this drawback is overcome by much better yields. © Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002.
2002
Cyanides
Diastereoselectivity
Ketones
Reduction
Synthetic methods
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.12317/63848
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