It is known that mice treated with some bacterial immunomodulators are partially protected from a subsequent challenge with viruses. These findings are based on the variety of effects that procariotic cells and their components are able to carry out on the immune system. On the other hand, many approaches to antiviral therapy have been investigated. Previously the authors have demonstrated the effects of P40, an immunomodulator derived from Corynebacterium granulosum, on the restoration of several depressed functions of peritoneal macrophages in tumour-bearing rats, as well as on HSV infection in mice. These data suggest the possibility of a cooperation between P40 and ribavirin in hindering HSV-2 systemic infection in Balb/c mice. The virus titre in the liver and the survival rate have been analysed. The results obtained demonstrate that the pretreatment with P40 led to a reduction of virus titre recovered from the liver and to a higher percentage of survival when compared with untreated mice. Moreover, the same basic behaviour was observed in mice treated with ribavirin alone. On the other hand, a higher level of protection during the outcome of a systemic infection was obtained by the association of the two treatments.
Enhancement of ribavirin efficacy versus HSV-2 systemic infection by P40 fraction treatment
Liberto M. C.;
1988-01-01
Abstract
It is known that mice treated with some bacterial immunomodulators are partially protected from a subsequent challenge with viruses. These findings are based on the variety of effects that procariotic cells and their components are able to carry out on the immune system. On the other hand, many approaches to antiviral therapy have been investigated. Previously the authors have demonstrated the effects of P40, an immunomodulator derived from Corynebacterium granulosum, on the restoration of several depressed functions of peritoneal macrophages in tumour-bearing rats, as well as on HSV infection in mice. These data suggest the possibility of a cooperation between P40 and ribavirin in hindering HSV-2 systemic infection in Balb/c mice. The virus titre in the liver and the survival rate have been analysed. The results obtained demonstrate that the pretreatment with P40 led to a reduction of virus titre recovered from the liver and to a higher percentage of survival when compared with untreated mice. Moreover, the same basic behaviour was observed in mice treated with ribavirin alone. On the other hand, a higher level of protection during the outcome of a systemic infection was obtained by the association of the two treatments.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
