The diagnosis of Ménière disease (MD) is based primarily on clinical symptoms and there is no single feature or subset of features from the history, clinical examination or instrumental tests that are able to establish a certain diagnosis. Identification of diagnostic markers that can discriminate MD more accurately, and also that are reliable, reproducible and easy-to-obtain, could be useful. The pathophysiology of MD is complex and debated. Starting from the pathophysiological hypotheses of the disease, different approaches have been used in order to find use ful biomarker candidates for diagnosis. We will present the main results in the literature and our personal experience in the field of molecular diagnostics applied to MD, and specifically of proteomics studies.
Coming out of the mists of Ménière disease: Serum proteomics and biomarkers discovery for early diagnosis and clinical management
Chiarella G.;Viola P.;Pisani D.;Malanga D.;Cassandro C.;Cuda G.;Cassandro E.
2020-01-01
Abstract
The diagnosis of Ménière disease (MD) is based primarily on clinical symptoms and there is no single feature or subset of features from the history, clinical examination or instrumental tests that are able to establish a certain diagnosis. Identification of diagnostic markers that can discriminate MD more accurately, and also that are reliable, reproducible and easy-to-obtain, could be useful. The pathophysiology of MD is complex and debated. Starting from the pathophysiological hypotheses of the disease, different approaches have been used in order to find use ful biomarker candidates for diagnosis. We will present the main results in the literature and our personal experience in the field of molecular diagnostics applied to MD, and specifically of proteomics studies.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
