Starting from the corresponding 3,5-dihydro-4H-2,3-benzodiazepin-4-ones, new 11H-triazolo[4,5-c] [2,3]benzodiazepines were synthesized and tested for anticonvulsant activity. Seizures were evoked both by means of auditory stimulation in DBA/2 mice and by pentylenetetrazole or maximal electroshock in Swiss mice. The pharmacological results revealed that the new tricyclic derivatives show less activity than their precursors.
Synthesis and anticonvulsant activity of new 11H-triazolo[4,5-c] [2,3]benzodiazepines
De Sarro G
1999-01-01
Abstract
Starting from the corresponding 3,5-dihydro-4H-2,3-benzodiazepin-4-ones, new 11H-triazolo[4,5-c] [2,3]benzodiazepines were synthesized and tested for anticonvulsant activity. Seizures were evoked both by means of auditory stimulation in DBA/2 mice and by pentylenetetrazole or maximal electroshock in Swiss mice. The pharmacological results revealed that the new tricyclic derivatives show less activity than their precursors.File in questo prodotto:
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