Multiple myeloma (MM) is due to the proliferation in the bone marrow (BM) of malignant plasmacells (PCs) and it accounts for about 10% of all hematological tumors. MM is the natural evolution of a monoclonal gammopathy of uncertain significance. Although the introduction of novel biological agents in the clinical practice has changed the natural history of the disease, MM remains incurable. MicroRNAs (miRNAs) are short non-coding RNAs that control cell functions through mRNA targeting. In the cancer setting, miRNAs have shown prognostic and predictive potentials. Several preclinical findings demonstrate their broad anticancer activities in various types of cancer, including MM. In this article, we provide an overview of the biology of miRNAs together with the scenario of miRNA deregulation in MM. These findings shine light on the use of miRNAs as anti-MM agents. We also discuss the recent findings on miRNA therapeutics of MM.
MicroRNA and Multiple Myeloma: from Laboratory Findings to Translational Therapeutic Approaches
Amodio N;Tagliaferri P;Tassone P;Rossi M
2014-01-01
Abstract
Multiple myeloma (MM) is due to the proliferation in the bone marrow (BM) of malignant plasmacells (PCs) and it accounts for about 10% of all hematological tumors. MM is the natural evolution of a monoclonal gammopathy of uncertain significance. Although the introduction of novel biological agents in the clinical practice has changed the natural history of the disease, MM remains incurable. MicroRNAs (miRNAs) are short non-coding RNAs that control cell functions through mRNA targeting. In the cancer setting, miRNAs have shown prognostic and predictive potentials. Several preclinical findings demonstrate their broad anticancer activities in various types of cancer, including MM. In this article, we provide an overview of the biology of miRNAs together with the scenario of miRNA deregulation in MM. These findings shine light on the use of miRNAs as anti-MM agents. We also discuss the recent findings on miRNA therapeutics of MM.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.