OBJECTIVE: This study aims to evaluate the concentration of α-defensin humanneutrophil peptide-1 (HNP-1; a peptide released by neutrophils) in salivary fluidamong postmenopausal women and to compare bone mineral density amongpostmenopausal women with different concentrations of this peptide.METHODS: We consecutively enrolled 61 postmenopausal women. Bone density wasmeasured by dual-energy x-ray absorptiometry, and α-defensin HNP-1 was identifiedby proteomic analysis of salivary fluid specimen.RESULTS: We found a significant difference in bone mineral density amongpostmenopausal women with different concentrations of α-defensin HNP-1 insalivary fluid. In particular, women with higher α-defensin concentrations hadthe lowest bone density in comparison with those with a lower concentration ofdefensin (P = 0.03 between groups). Univariate and multivariate linear regressionanalyses showed a significative inverse relationship between bone mineral densityand age (r = -0.58, β = -0.56) and peak of α-defensin (r = -0.26, β = -0.21).CONCLUSIONS: Low bone mineral density is found in postmenopausal women with high α-defensin HNP-1 concentrations. Therefore, α-defensin HNP-1 could be a novelbiomarker for osteoporosis

Association between low bone mineral density and increased α-defensin in salivary fluid among postmenopausal women

Terracciano R;Migliaccio V;Savino R;Pujia A;Montalcini T
2013-01-01

Abstract

OBJECTIVE: This study aims to evaluate the concentration of α-defensin humanneutrophil peptide-1 (HNP-1; a peptide released by neutrophils) in salivary fluidamong postmenopausal women and to compare bone mineral density amongpostmenopausal women with different concentrations of this peptide.METHODS: We consecutively enrolled 61 postmenopausal women. Bone density wasmeasured by dual-energy x-ray absorptiometry, and α-defensin HNP-1 was identifiedby proteomic analysis of salivary fluid specimen.RESULTS: We found a significant difference in bone mineral density amongpostmenopausal women with different concentrations of α-defensin HNP-1 insalivary fluid. In particular, women with higher α-defensin concentrations hadthe lowest bone density in comparison with those with a lower concentration ofdefensin (P = 0.03 between groups). Univariate and multivariate linear regressionanalyses showed a significative inverse relationship between bone mineral densityand age (r = -0.58, β = -0.56) and peak of α-defensin (r = -0.26, β = -0.21).CONCLUSIONS: Low bone mineral density is found in postmenopausal women with high α-defensin HNP-1 concentrations. Therefore, α-defensin HNP-1 could be a novelbiomarker for osteoporosis
2013
Defensin; Bone; Osteoporosis; Salivary fluid; Menopause; Immune system
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.12317/7318
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