Title compounds 1-36 were synthesized by reacting hydrazine with aldol adducts obtained from ninhydrin and methyl or alpha methylene ketones and aldehydes. Some of them showed a low, but significant benzodiazepine receptor affinity whose variation was interpreted through a structure-activity relationships study based on qualitative correlations and Comparative Molecular Field Analysis (CoMFA). Some indeno-pyridazine derivatives were found to possess an interesting anticonvulsant activity which however does not seem simply related to the benzodiazepine receptor modulation.
|Titolo:||SYNTHESIS, BENZODIAZEPINE RECEPTOR AFFINITY AND ANTICONVULSANT ACTIVITY OF 5-H-INDENO[1,2-C]PYRIDAZINE DERIVATIVES|
|Data di pubblicazione:||1994|
|Appare nelle tipologie:||1.1 Articolo in rivista|