Patients diagnosed with malignancy, neurological and immunological disorders, i.e., fragile patients, have been excluded from COVID-19 vaccine trials. However, this population may present immune response abnormalities, and relative reduced vaccine responsiveness. Here we review the limited current evidence on the immune responses to vaccination of patients with different underlying diseases. To address open questions we present the VAX4FRAIL study aimed at assessing immune responses to vaccination in a large transdisease cohort of patients with cancer, neurological and rheumatological diseases.

COVID-19 Vaccination in Fragile Patients: Current Evidence and an Harmonized Transdisease Trial

Ciliberto G.;
2021-01-01

Abstract

Patients diagnosed with malignancy, neurological and immunological disorders, i.e., fragile patients, have been excluded from COVID-19 vaccine trials. However, this population may present immune response abnormalities, and relative reduced vaccine responsiveness. Here we review the limited current evidence on the immune responses to vaccination of patients with different underlying diseases. To address open questions we present the VAX4FRAIL study aimed at assessing immune responses to vaccination in a large transdisease cohort of patients with cancer, neurological and rheumatological diseases.
2021
cancer
COVID-19
immunocompromised
myasthenia
SARS-CoV-2
vaccine
Adult
COVID-19 Vaccines
Clinical Protocols
Humans
Immune System Diseases
Immunocompromised Host
Neoplasms
Nervous System Diseases
Patient Selection
Prospective Studies
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.12317/74063
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