Among deregulated microRNAs (miRs) in human malignancies, miR-221 has been widely investigated for its oncogenic role and as a promising biomarker. Moreover, recent evidence suggests miR-221 as a fine-tuner of chronic liver injury and inflammation-related events. Available information also supports the potential of miR-221 silencing as promising therapeutic intervention. In this systematic review, we selected papers from the principal databases (PubMed, MedLine, Medscape, ASCO, ESMO) between January 2012 and December 2020, using the keywords “miR-221” and the specific keywords related to the most important hematologic and solid malignancies, and some non-malignant diseases, to define and characterize deregulated miR-221 as a valuable therapeutic target in the modern vision of molecular medicine. We found a major role of miR-221 in this view.

miR-221/222 as biomarkers and targets for therapeutic intervention on cancer and other diseases: A systematic review

Di Martino M. T.
;
Arbitrio M.;Caracciolo D.;Cordua A.;Cuomo O.;Grillone K.;Riillo C.;Scionti F.;Labanca C.;Romeo C.;Siciliano M. A.;D'Apolito M.;Napoli C.;Montesano M.;Farenza V.;Uppolo V.;Tafuni M.;Falcone F.;D'Aquino G.;Calandruccio N. D.;Luciano F.;Pensabene L.;Tagliaferri P.;Tassone P.
2022-01-01

Abstract

Among deregulated microRNAs (miRs) in human malignancies, miR-221 has been widely investigated for its oncogenic role and as a promising biomarker. Moreover, recent evidence suggests miR-221 as a fine-tuner of chronic liver injury and inflammation-related events. Available information also supports the potential of miR-221 silencing as promising therapeutic intervention. In this systematic review, we selected papers from the principal databases (PubMed, MedLine, Medscape, ASCO, ESMO) between January 2012 and December 2020, using the keywords “miR-221” and the specific keywords related to the most important hematologic and solid malignancies, and some non-malignant diseases, to define and characterize deregulated miR-221 as a valuable therapeutic target in the modern vision of molecular medicine. We found a major role of miR-221 in this view.
2022
biliary tract cancer
bladder cancer
breast cancer
cancer
cervical cancer
demyelinating diseases
endometrial cancer
gastrointestinal cancer
glioblastoma
gynecological cancers
hematological diseases
hepatocellular carcinoma
lung cancer
melanoma
microRNA
miR
miR therapeutics
miR-221
miR-221/222
miRs
myeloma
NASH
neuropathy
ovarian cancer
pancreatic cancer
pharmacokinetics
prostate cancer
renal cell carcinoma
sarcomas
solid cancers
urogenital cancer
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.12317/75688
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