A NMR spectroscopic and crystallographic investigation supported by molecular modelling methods has been employed to describe the inclusion properties of molsidomine into the three underivatized alpha-, beta- and gamma-cyclodextrins, aimed to point out the factors affecting the complexation selectivity and stabilization. The NMR results were compared and validated by the analysis of crystallographic data as retrieved from the Cambridge Structural Database and molecular modelling studies. (c) 2005 Elsevier Ltd. All rights reserved.
Combined NMR-crystallographic and modelling investigation of the inclusion of molsidomine into alpha-, beta- and gamma-cyclodextrins
Paolino D;
2005-01-01
Abstract
A NMR spectroscopic and crystallographic investigation supported by molecular modelling methods has been employed to describe the inclusion properties of molsidomine into the three underivatized alpha-, beta- and gamma-cyclodextrins, aimed to point out the factors affecting the complexation selectivity and stabilization. The NMR results were compared and validated by the analysis of crystallographic data as retrieved from the Cambridge Structural Database and molecular modelling studies. (c) 2005 Elsevier Ltd. All rights reserved.File in questo prodotto:
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