Protein Contact Network (PCN) is a powerful method for analysing the structure and function of proteins, with a specific focus on disclosing the molecular features of allosteric regulation through the discovery of modular substructures. The importance of PCN analysis has been shown in many contexts, such as the analysis of SARS-CoV-2 Spike protein and its complexes with the ACE human receptors. Even if there exist many software tools implementing such methods, there is a growing need tools integrating existing approaches.
PCN-Miner: An open-source extensible tool for the Analysis of Protein Contact Networks
Guzzi, Pietro Hiram;Veltri, Pierangelo
2022-01-01
Abstract
Protein Contact Network (PCN) is a powerful method for analysing the structure and function of proteins, with a specific focus on disclosing the molecular features of allosteric regulation through the discovery of modular substructures. The importance of PCN analysis has been shown in many contexts, such as the analysis of SARS-CoV-2 Spike protein and its complexes with the ACE human receptors. Even if there exist many software tools implementing such methods, there is a growing need tools integrating existing approaches.File in questo prodotto:
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