Cognitive reserve (CR) is a key factor to mitigate the cognitive decline during the aging process. Here, we used event-related potentials to target the preparatory brain activities associated with different levels of CR during visuo-motor simple response tasks (SRTs) and discriminative response tasks (DRTs). EEG was recorded from 28 healthy old (Age: 72.2 +/- 4.7 years) and 14 young (Age: 22.2 +/- 2.4 years) individuals during an SRT and a DRT. Depending on the CR median score, old participants were divided into either a high (High-CR) or a low CR (Low-CR) group. Behavioral performance and electrophysiological data were compared across the 3 groups. Compared with the Low-CR, the High-CR group showed larger prestimulus prefrontal (prefrontal negativity) and premotor activity (Bereitschaftspotential-BP), in the SRT, and increased premotor readiness (BP), in the DRT. The High-CR was faster and more accurate than the Low-CR group in the DRT and SRT, respectively. The High-CR group revealed enhanced brain preparatory activities that, paralleled to their behavioral performance, might reflect neural compensation and maintenance effects possibly counteracting the age-related decline in cognitive functioning. (C) 2020 Elsevier Inc. All rights reserved.

The role of cognitive reserve on prefrontal and premotor cortical activity in visuo-motor response tasks in healthy old adults

Quinzi, Federico;
2020-01-01

Abstract

Cognitive reserve (CR) is a key factor to mitigate the cognitive decline during the aging process. Here, we used event-related potentials to target the preparatory brain activities associated with different levels of CR during visuo-motor simple response tasks (SRTs) and discriminative response tasks (DRTs). EEG was recorded from 28 healthy old (Age: 72.2 +/- 4.7 years) and 14 young (Age: 22.2 +/- 2.4 years) individuals during an SRT and a DRT. Depending on the CR median score, old participants were divided into either a high (High-CR) or a low CR (Low-CR) group. Behavioral performance and electrophysiological data were compared across the 3 groups. Compared with the Low-CR, the High-CR group showed larger prestimulus prefrontal (prefrontal negativity) and premotor activity (Bereitschaftspotential-BP), in the SRT, and increased premotor readiness (BP), in the DRT. The High-CR was faster and more accurate than the Low-CR group in the DRT and SRT, respectively. The High-CR group revealed enhanced brain preparatory activities that, paralleled to their behavioral performance, might reflect neural compensation and maintenance effects possibly counteracting the age-related decline in cognitive functioning. (C) 2020 Elsevier Inc. All rights reserved.
2020
Bereitschaftspotential
EEG
Event-related potentials
Prefrontal negativity
Proactive brain functions
Adult
Age Factors
Aged
Cognitive Aging
Cognitive Reserve
Electroencephalography
Evoked Potentials
Female
Healthy Aging
Humans
Male
Motor Cortex
Psychomotor Performance
Visual Perception
Young Adult
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.12317/81252
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