Background and objectiveHealth-related quality of life (HRQL) in respiratory diseases has been generally investigated in clinical settings, focusing on a single disorder. In this study on a general population sample, we assessed the relationship between HRQL and several respiratory diseases studied simultaneously (COPD, current (CA) and past (PA) asthma, allergic (AR) and non-allergic (NAR) rhinitis and chronic bronchitis (CB).MethodsControls (n=328) and cases of NAR (n=95), AR (n=163), CB (n=48), CA (n=224), PA (n=126) and COPD (n=28) were recruited in the centre of Verona in the frame of the Italian multi-case control GEIRD (Gene Environment Interactions in Respiratory Diseases) study; HRQL was measured through the SF-36 questionnaire. The relationships between HRQL (in terms of Physical (PCS) and Mental Component Scores (MCS)), respiratory diseases, and covariates were evaluated.ResultsWith respect to controls, the adjusted PCS median score was worse in subjects suffering from current asthma (-1.7; 95%CI:-2.8;-0.6), CB (-3.8; 95%CI:-5.7;-1.9), and COPD (-5.6; 95%CI:-8.1;-3.1). MCS was worse in current asthmatics (-2.2; 95%CI:-4.1;-0.3), CB (-5.5; 95%CI:-8.7;-2.2), and COPD cases (-4.6; 95%CI:-8.8;-0.5) as well.ConclusionsTo our knowledge, this is the first study in the general population that analyzed HRQL performing a simultaneous comparison of HRLQ in several respiratory disorders. We found that subjects suffering from COPD, CA, and CB had the poorest HRQL. Clinicians should carefully consider the possible impact of respiratory disorders as CB and not only that of CA and COPD.

Health-related quality of life varies in different respiratory disorders: a multi-case control population based study

Di Gennaro, Gianfranco;Ferrari, Marcello;
2019-01-01

Abstract

Background and objectiveHealth-related quality of life (HRQL) in respiratory diseases has been generally investigated in clinical settings, focusing on a single disorder. In this study on a general population sample, we assessed the relationship between HRQL and several respiratory diseases studied simultaneously (COPD, current (CA) and past (PA) asthma, allergic (AR) and non-allergic (NAR) rhinitis and chronic bronchitis (CB).MethodsControls (n=328) and cases of NAR (n=95), AR (n=163), CB (n=48), CA (n=224), PA (n=126) and COPD (n=28) were recruited in the centre of Verona in the frame of the Italian multi-case control GEIRD (Gene Environment Interactions in Respiratory Diseases) study; HRQL was measured through the SF-36 questionnaire. The relationships between HRQL (in terms of Physical (PCS) and Mental Component Scores (MCS)), respiratory diseases, and covariates were evaluated.ResultsWith respect to controls, the adjusted PCS median score was worse in subjects suffering from current asthma (-1.7; 95%CI:-2.8;-0.6), CB (-3.8; 95%CI:-5.7;-1.9), and COPD (-5.6; 95%CI:-8.1;-3.1). MCS was worse in current asthmatics (-2.2; 95%CI:-4.1;-0.3), CB (-5.5; 95%CI:-8.7;-2.2), and COPD cases (-4.6; 95%CI:-8.8;-0.5) as well.ConclusionsTo our knowledge, this is the first study in the general population that analyzed HRQL performing a simultaneous comparison of HRLQ in several respiratory disorders. We found that subjects suffering from COPD, CA, and CB had the poorest HRQL. Clinicians should carefully consider the possible impact of respiratory disorders as CB and not only that of CA and COPD.
2019
Allergy
Asthma
COPD
Clinical epidemiology
Quality of life
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.12317/86421
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 9
  • ???jsp.display-item.citation.isi??? 8
social impact