The development of the B-lymphoid cell lineage is tightly controlled by the concerted action of a network of transcriptional and epigeneticregulators.EBF1,acentralcomponentofthisnetwork,isessentialforB-lymphoidspecificationandcommitmentaswell asforthemaintenanceoftheB-cellidentity.GeneticalterationscausinglossoffunctionoftheseB-lymphopoiesisregulatorshave beenimplicatedinthepathogenesisofB-lymphoidmalignancies,withparticularregardtoB-cellacutelymphoblasticleukaemias (B-ALLs),wheretheirpresenceisfrequentlydetected.TheactivityoftheB-cellregulatorynetworkmayalsobedisruptedbythe aberrantexpressionofinhibitorymolecules.Inparticular,twomulti-zincfingertranscriptioncofactorsnamedZNF423andZNF521 havebeencharacterisedaspotentinhibitorsofEBF1andareemergingaspotentiallyrelevantcontributorstothedevelopmentof B-cellleukaemias.Herewewillbrieflyreviewthecurrentknowledgeofthesefactorsanddiscusstheimportanceoftheirfunctional crosstalkwithEBF1inthedevelopmentofB-cellmalignancies.

ZNF423 and ZNF521: EBF1 antagonists of potential relevance in B-lymphoid malignancies.

Mesuraca M;Chiarella E;Scicchitano S;Codispoti B;Nappo G;Bond H;
2015-01-01

Abstract

The development of the B-lymphoid cell lineage is tightly controlled by the concerted action of a network of transcriptional and epigeneticregulators.EBF1,acentralcomponentofthisnetwork,isessentialforB-lymphoidspecificationandcommitmentaswell asforthemaintenanceoftheB-cellidentity.GeneticalterationscausinglossoffunctionoftheseB-lymphopoiesisregulatorshave beenimplicatedinthepathogenesisofB-lymphoidmalignancies,withparticularregardtoB-cellacutelymphoblasticleukaemias (B-ALLs),wheretheirpresenceisfrequentlydetected.TheactivityoftheB-cellregulatorynetworkmayalsobedisruptedbythe aberrantexpressionofinhibitorymolecules.Inparticular,twomulti-zincfingertranscriptioncofactorsnamedZNF423andZNF521 havebeencharacterisedaspotentinhibitorsofEBF1andareemergingaspotentiallyrelevantcontributorstothedevelopmentof B-cellleukaemias.Herewewillbrieflyreviewthecurrentknowledgeofthesefactorsanddiscusstheimportanceoftheirfunctional crosstalkwithEBF1inthedevelopmentofB-cellmalignancies.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.12317/9115
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