Lacosamide is Associated with a Higher Treatment Persistence at 12 Months than Brivaracetam and Perampanel Despite Similar Efficacy

Introduction: Evidence directly comparing newer antiseizure medications (ASMs) is limited but crucial for guiding treatment decisions. This study compared the real-world effectiveness and tolerability of brivaracetam (BRV), lacosamide (LCM) and perampanel (PER) as add-on therapy in adults with epilepsy, applying a causal-inference extension of the COMPARE study. The aim of this approach was to overcome the limitations of standard multivariable analyses, better approximate causal effects, and ...

Efficacy of Constraint-Induced Movement Therapy and mirror therapy in improving upper limb motor function and dexterity in post-stroke hemiparetic patients: a randomized controlled trial

Background: Stroke is among the leading causes of death and disability globally, leaving the patients with post-stroke hemiparesis approximately in 60% of stroke survivors. Upper limb (UL) impairment, in particular fine motor function, poses significant challenges in daily living activities. Although Constraint-Induced Movement Therapy (CIMT) and Mirror Therapy (MT) have been employed to address these issues, limited research compares the effectiveness of each therapy. This study aimed to eva...

The Silent Revolution of the Genome: The Role of Optical Genome Mapping in Acute Lymphoblastic Leukemia

Low dose NSAIDs and sysadoas in the management of knee osteoarthritis

Introduction: Osteoarthritis (OA) is a chronic, progressive joint disease characterized by the degradation of articular cartilage, subchondral bone remodeling, synovial inflammation, and osteophyte formation. Despite being a leading cause of disability in older people, effective long-term management of OA remains a significant challenge. Current treatment strategies primarily focus on symptom control, with both non-pharmacological and pharmacological interventions. Materials and methods: A sy...