Dysregulation of the Cannabinoid System in Childhood Epilepsy: From Mechanisms to Therapy

Epilepsy affects over 12 million children worldwide, with approximately 30% classified as having drug-resistant epilepsy (DRE), often accompanied by neuropsychiatric comorbidities that severely impact quality of life. The endocannabinoid system (ECS) functions as a multifaceted neuromodulatory network regulating neuronal excitability, synaptic plasticity, and immune homeostasis from early life through adolescence and into aging. In pediatric epilepsies, alterations in ECS components, particul...

Food insecurity is associated with obesity and abdominal obesity among older adults. A cross-sectional analysis of ELSA study

When can calcium pyrophosphate deposition disease be considered a polymyalgia rheumatica mimicking disease?

Introduction: Similarly to polymyalgia rheumatica (PMR), calcium pyrophosphate deposition (CPPD) disease is common among older people. Calcium pyrophosphate deposition can present in several forms, including proximal manifestations associated with raised inflammatory markers. Consequently, CPPD disease may be diagnosed as PMR. Recently, a European Alliance of Associations for Rheumatology and American College of Rheumatology (EULAR/ACR) collaborative initiative proposed new classification cri...

Drug prescription and delirium in older inpatients: Results from the nationwide multicenter Italian Delirium Day 2015-2016

Objective: This study aimed to evaluate the association between polypharmacy and delirium, the association of specific drug categories with delirium, and the differences in drug-delirium association between medical and surgical units and according to dementia diagnosis. Methods: Data were collected during 2 waves of Delirium Day, a multicenter delirium prevalence study including patients (aged 65 years or older) admitted to acute and long-term care wards in Italy (2015-2016); in this study, o...