Endometriosis‐Associated Periodontal Disease: A Large Cohort Perspective Study

Objective: Endometriosis is a chronic estrogen-dependent gynecological disease affecting millions of women worldwide. Besidesits well-established impact on reproductive health, emerging evidence suggests a potential association between endometriosisand periodontal disease. The present study discusses the interplay between the two diseases, exploring shared immunopatholog-ical mechanisms, including chronic inflammation, hormonal imbalance, and immune system modulation.Materials and Methods: A 45-question standardized questionnaire was answered by 4072 women clinically diagnosed withendometriosis to identify self-reported periodontal status, oral hygiene habits, and systemic symptoms.Results: Findings report that more severe stages of endometriosis are related to increased awareness of periodontal disease,greater gingival bleeding, xerostomia, and mucosal alterations. Moreover, greater diagnostic latency aggravates both systemicand oral disorders, supporting the necessity of early treatment. These findings highlight the need for a single, multidisciplinarystandard of patient care involving gynecologists, dentists, dental hygienists, and other healthcare providers.Conclusion: By connecting gynecological and dental care, this study aims to promote awareness, facilitate early diagnosis, andimprove quality of life for women suffering from endometriosis. Future research must explore mechanisms linking the condi-tions and assess therapeutic approaches to alleviate oral health issues in these individuals