BACKGROUND: Low fat utilization is linked to weight gain and to the presence ofcertain atherosclerosis markers. It is not clear whether the presence ofhyperlipidemia can further affect nutrients utilization. The main objective ofthis study was to investigate the fasting fuel utilization of obese subjectssuffering from hypertriglyceridemia, and to compare it with that of individualsthat are solely obese.METHOD: We recruited 20 obese individuals with hypertriglyceridemia and 20matched individuals not affected by hypertriglyceridemia. The fuel utilization(respiratory quotient) was measured by respiratory gas exchange, by IndirectCalorimetry.RESULTS: There was a significant difference in fuel utilization andHDL-cholesterol between cases and controls (respiratory quotient 0.89 ± 0.07 vs. 0.84 ± 0.06; p = 0.020 respectively). The univariate and multivariate linearregression analysis confirmed that hypertrygliceridemia was positively correlatedto the respiratory quotient (p = 0.035).CONCLUSION: obese subjects with hypertriglyceridemia had a higher respiratoryquotient in comparison to unaffected subjects. This could suggest a limitation inthe beta-oxidation mechanisms; this could actually imply that fatty acids may be redirected from oxidation to reesterification into triglycerides. The study couldsuggest the presence of different mechanisms unrelated to obesity and also a potential new therapeutic target for hypertriglyceridemia management.
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