Background: In December 2019, a new coronavirus (named severe acute respiratory syndrome coronavirus 2, SARS-CoV-2) spread from China, causing a pandemic in a very short time. The main clinical presentation of SARS-CoV-2 infection (COVID-19, coronavirus disease-2019) is pneumonia, but several cardiovascular complications may also occur (e.g., acute coronary syndromes, pulmonary embolism, stroke, arrhythmias, heart failure and cardiogenic shock). Direct or indirect mechanisms induced by SARS-CoV-2 could be implicated in the pathogenesis of these events. Case presentation: We report herein the third case of COVID-19 autoimmune haemolytic anaemia (AIHA) reported so far, which occurredwithout any other possible explanations in a Caucasian patient. The patient also suffered from ST-elevation myocardial injury. Conclusions: Both complications occurred quite late after COVID-19 diagnosis and were probably precipitated by systemic inflammation, as indicated by a significant delayed increase in inflammatory markers, including interleukin-6 (IL-6).

Late-onset myocardial infarction and autoimmune haemolytic anaemia in a COVID-19 patient without respiratory symptoms, concomitant with a paradoxical increase in inflammatory markers: a case report

Tassone B.;Ricchio M.;Mazzitelli M.;Davoli C.;Cancelliere A.;La Gamba V.;Lio E.;Matera G.;Quirino A.;Trecarichi E. M.;Torti C.;Arrighi E.;Bertucci B.;Carallo C.;De Francesco A.;Fusco P.;Gallo L.;Giancotti A.;Giudice A.;Lagana D.;Lamberti A.;Liberto M. C.;Lionello R.;Marascio N.;Marrazzo G.;Scaglione V.;Serapide F.;Indolfi C.;Longhini F.;Bruni A.;Garofalo E.
2020-01-01

Abstract

Background: In December 2019, a new coronavirus (named severe acute respiratory syndrome coronavirus 2, SARS-CoV-2) spread from China, causing a pandemic in a very short time. The main clinical presentation of SARS-CoV-2 infection (COVID-19, coronavirus disease-2019) is pneumonia, but several cardiovascular complications may also occur (e.g., acute coronary syndromes, pulmonary embolism, stroke, arrhythmias, heart failure and cardiogenic shock). Direct or indirect mechanisms induced by SARS-CoV-2 could be implicated in the pathogenesis of these events. Case presentation: We report herein the third case of COVID-19 autoimmune haemolytic anaemia (AIHA) reported so far, which occurredwithout any other possible explanations in a Caucasian patient. The patient also suffered from ST-elevation myocardial injury. Conclusions: Both complications occurred quite late after COVID-19 diagnosis and were probably precipitated by systemic inflammation, as indicated by a significant delayed increase in inflammatory markers, including interleukin-6 (IL-6).
2020
AIHA
Anaemia
Cardiovascular disease
COVID-19
IL-6
Inflammation
Aged, 80 and over
Anemia, Hemolytic, Autoimmune
Anti-Bacterial Agents
Azithromycin
C-Reactive Protein
COVID-19
Coombs Test
Electrocardiography
Enzyme Inhibitors
Female
Glucocorticoids
Humans
Hydroxychloroquine
Interleukin-6
Platelet Aggregation Inhibitors
Prednisolone
SARS-CoV-2
ST Elevation Myocardial Infarction
Asymptomatic Infections
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.12317/66799
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