: This study evaluated the spread and possible changes in resistance patterns of ESKAPE bacteria to first-choice antibiotics from 2015 to 2019 at a third-level university hospital after persuasive stewardship measures were implemented. Isolates were divided into three groups (group 1, low drug-resistant; group 2, multidrug/extremely drug-resistant; and group 3, pan-resistant bacteria) and a chi-squared test (χ2) was applied to determine differences in their distributions. Among the 2,521 isolates, Klebsiella pneumoniae was the most frequently detected (31.1%). From 2015 to 2019, the frequency of isolates in groups 2 and 3 decreased from 70.1% to 48.6% (χ2 = 63.439; p < 0.0001). Stratifying isolates by bacterial species, for K. pneumoniae, the frequency of PDR isolates decreased from 20% to 1.3% (χ2 = 15.885; p = 0.003). For Acinetobacter baumannii, a statistically significant decrease was found in groups 2 and 3: from 100% to 83.3% (χ2 = 27.721; p < 0.001). Also, for Pseudomonas aeruginosa and Enterobacter spp., the frequency of groups 2 and 3 decreased from 100% to 28.3% (χ2 = 225.287; p < 0.001) and from 75% to 48.7% (χ2 = 15.408; p = 0.003), respectively. These results indicate that a program consisting of persuasive stewardship measures, which were rolled out during the time frame of our study, may be useful to control drug-resistant bacteria in a hospital setting.

This study evaluated the spread and possible changes in resistance patterns of ESKAPE bacteria to first-choiceantibiotics from 2015 to 2019 at a third-level university hospital after persuasive stewardship measures wereimplemented. Isolates were divided into three groups (group 1, low drug-resistant; group 2, multidrug/extremely drug-resistant; and group 3, pan-resistant bacteria) and achi-squaredtest (v2) was applied to deter-mine differences in their distributions. Among the 2,521 isolates,Klebsiella pneumoniaewas the most fre-quently detected (31.1%). From 2015 to 2019, the frequency of isolates in groups 2and3 decreased from 70.1%to 48.6% (v2=63.439;p<0.0001). Stratifying isolates by bacterial species, forK. pneumoniae, the frequency ofPDR isolates decreased from 20% to 1.3% (v2=15.885;p=0.003). ForAcinetobacter baumannii, a statisticallysignificant decrease was found in groups 2and3: from 100% to 83.3% (v2=27.721;p<0.001). Also, forPseudomonas aeruginosaandEnterobacterspp., the frequency of groups 2and3 decreased from 100% to28.3% (v2=225.287;p<0.001) and from 75% to 48.7% (v2=15.408;p=0.003), respectively. These resultsindicate that a program consisting of persuasive stewardship measures, which were rolled out during the timeframe of our study, may be useful to control drug-resistant bacteria in a hospital setting.

Prevalence of Antibiotic Resistance Over Time in a Third-Level University Hospital

Scaglione, Vincenzo;Davoli, Chiara;Mazzitelli, Maria;Serapide, Francesca;Lionello, Rosaria;La Gamba, Valentina;Fusco, Paolo;Bruni, Andrea;Procopio, Daniela;Garofalo, Eugenio;Longhini, Federico;Marascio, Nadia;Peronace, Cinzia;Matera, Giovanni;Liberto, Maria Carla;Trecarichi, Enrico Maria;Quirino, Angela;Torti, Carlo
2022-01-01

Abstract

This study evaluated the spread and possible changes in resistance patterns of ESKAPE bacteria to first-choiceantibiotics from 2015 to 2019 at a third-level university hospital after persuasive stewardship measures wereimplemented. Isolates were divided into three groups (group 1, low drug-resistant; group 2, multidrug/extremely drug-resistant; and group 3, pan-resistant bacteria) and achi-squaredtest (v2) was applied to deter-mine differences in their distributions. Among the 2,521 isolates,Klebsiella pneumoniaewas the most fre-quently detected (31.1%). From 2015 to 2019, the frequency of isolates in groups 2and3 decreased from 70.1%to 48.6% (v2=63.439;p<0.0001). Stratifying isolates by bacterial species, forK. pneumoniae, the frequency ofPDR isolates decreased from 20% to 1.3% (v2=15.885;p=0.003). ForAcinetobacter baumannii, a statisticallysignificant decrease was found in groups 2and3: from 100% to 83.3% (v2=27.721;p<0.001). Also, forPseudomonas aeruginosaandEnterobacterspp., the frequency of groups 2and3 decreased from 100% to28.3% (v2=225.287;p<0.001) and from 75% to 48.7% (v2=15.408;p=0.003), respectively. These resultsindicate that a program consisting of persuasive stewardship measures, which were rolled out during the timeframe of our study, may be useful to control drug-resistant bacteria in a hospital setting.
2022
: This study evaluated the spread and possible changes in resistance patterns of ESKAPE bacteria to first-choice antibiotics from 2015 to 2019 at a third-level university hospital after persuasive stewardship measures were implemented. Isolates were divided into three groups (group 1, low drug-resistant; group 2, multidrug/extremely drug-resistant; and group 3, pan-resistant bacteria) and a chi-squared test (χ2) was applied to determine differences in their distributions. Among the 2,521 isolates, Klebsiella pneumoniae was the most frequently detected (31.1%). From 2015 to 2019, the frequency of isolates in groups 2 and 3 decreased from 70.1% to 48.6% (χ2 = 63.439; p &lt; 0.0001). Stratifying isolates by bacterial species, for K. pneumoniae, the frequency of PDR isolates decreased from 20% to 1.3% (χ2 = 15.885; p = 0.003). For Acinetobacter baumannii, a statistically significant decrease was found in groups 2 and 3: from 100% to 83.3% (χ2 = 27.721; p &lt; 0.001). Also, for Pseudomonas aeruginosa and Enterobacter spp., the frequency of groups 2 and 3 decreased from 100% to 28.3% (χ2 = 225.287; p &lt; 0.001) and from 75% to 48.7% (χ2 = 15.408; p = 0.003), respectively. These results indicate that a program consisting of persuasive stewardship measures, which were rolled out during the time frame of our study, may be useful to control drug-resistant bacteria in a hospital setting.
ESKAPE
Southern Italy
antimicrobial resistance
hospital units
antimicrobial resistance, ESKAPE, Southern Italy, hospital units
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.12317/82547
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