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Expulsion of iron-rich ferritin via CD63-mediated exosome drives ferroptosis resistance in ovarian cancer cells

Introduction: Ferroptosis is a promising new target for ovarian cancer (OVCA) treatment. However, some OVCA cell types resist the induction of ferroptosis by limiting the intracellular accumulation of the labile iron pool (LIP). Methods: HEY, COV318 and PEO4 were treated with erastin and assessed for cell viability by using PI flow cytometry assays. Erastin-affected iron metabolism was analysed by using FerroOrange assay, Western Blot (WB) analysis of ferritin heavy chain (FtH), transferrin r...

V. PUPO, Il caso Paragon solutions: spyware e segreti

Il lavoro ricostruisce la vicenda di spionaggio compiuto attraverso lo spyware Graphite prodotto dall’azienda Paragon Solutions, che ha coinvolto oltre novanta target nel mondo, di cui sette in Italia, tra i quali giornalisti e attivisti per i diritti umani. Vengono esaminate le numerose questioni istituzionali, politiche e giuridiche, connesse al pericolo di gravi violazioni di diritti e libertà fondamentali e al possibile coinvolgimento degli apparati italiani di intelligence, nonché al mod...

Severe Acute Respiratory Syndrome Coronavirus 2 Pandemic

Context.-The novel coronavirus disease 2019 (COVID-19) pandemic is significantly changing methodologic approaches in all branches of the health system. From a forensic point of view, this event is partly changing the manner in which forensic pathologists and all those who work in autopsy services operate, but above all, it is changing the patterns established for years by which cadavers are analyzed postmortem. Objective.-To present a review of the literature and a proposal for COVID-19 autop...

A rare case of suicide by ingestion of muriatic acid: analysis of the medico-legal evidences

Caustic substances are highly corrosive and dangerous, causing protein denaturation and tissue necrosis by altering pH upon contact. Common examples include muriatic acid, caustic soda, and ammonia. This case study details a 44-year-old man who ingested muriatic acid in a suicide attempt, leading to widespread esophageal and gastric ulcerations, tissue necrosis, pulmonary consolidations, and bloodstream infections (Klebsiella Pneumoniae, Acinetobacter Baumanii complex). Despite medical interv...

Human Deaths Related to Oleander Poisoning: A Review of the Literature

Oleander poisoning, resulting from the ingestion of Nerium oleander or Thevetia peruviana, is a serious toxicological issue in various parts of the world, particularly in regions where these plants grow abundantly and are easily accessible. Oleander contains potent cardiac glycosides, such as oleandrin and thevetin, which exert powerful effects on the cardiovascular system, leading to symptoms ranging from nausea and abdominal pain to severe arrhythmias and sudden cardiac death. This review s...

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