The synthesis and activity of 1,3-indandione derivatives as acetylcholinesterase (AChE) inhibitors are reported. The synthetic keystep consists of the Knovenagel olefination between 1,3-indandione and a substituted (1-benzylpiperidin-4-yl)methanal followed by selective double bond reduction. AChE inhibitory activity was measured by a quick fluorimetric method. One of the new compounds showed a significant interaction with the enzyme. Molecular modelling studies were performed in order to propose the binding modes within the AChE gorge compared to the known inhibitor Donepezil
Titolo: | Synthesis and Biological Evaluation of 1,3-Indandione Derivatives as Acetylcholinesterase Inhibitors |
Autori: | |
Data di pubblicazione: | 2009 |
Rivista: | |
Handle: | http://hdl.handle.net/20.500.12317/10944 |
Appare nelle tipologie: | 1.1 Articolo in rivista |
File in questo prodotto:
Non ci sono file associati a questo prodotto.
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.