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EnglishThe synthesis and activity of 1,3-indandione derivatives as acetylcholinesterase (AChE) inhibitors are reported. The synthetic keystep consists of the Knovenagel olefination between 1,3-indandione and a substituted (1-benzylpiperidin-4-yl)methanal followed by selective double bond reduction. AChE inhibitory activity was measured by a quick fluorimetric method. One of the new compounds showed a significant interaction with the enzyme. Molecular modelling studies were performed in order to propose the binding modes within the AChE gorge compared to the known inhibitor Donepezil
| Titolo: | Synthesis and Biological Evaluation of 1,3-Indandione Derivatives as Acetylcholinesterase Inhibitors |
| Autori: | |
| Data di pubblicazione: | 2009 |
| Rivista: | |
| Handle: | http://hdl.handle.net/20.500.12317/10944 |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
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http://hdl.handle.net/20.500.12317/10944
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