Theoretical and experimental data provide evidence of the existence of a strong O⋅⋅⋅HN hydrogen bond in chromones with carboxamide substituents located at position 3 of the γ-pyrone ring. The results suggest that the hydrogen-bond interaction is essential to the stabilization of the chromone folded stage and is strictly related to the potency and selectivity observed in monoamine oxidase-B biological assays
Towards the discovery of a novel class of monoamine oxidase inhibitors: structure-property-activity and docking studies on chromone amides
ORTUSO F;Alcaro S
2011-01-01
Abstract
Theoretical and experimental data provide evidence of the existence of a strong O⋅⋅⋅HN hydrogen bond in chromones with carboxamide substituents located at position 3 of the γ-pyrone ring. The results suggest that the hydrogen-bond interaction is essential to the stabilization of the chromone folded stage and is strictly related to the potency and selectivity observed in monoamine oxidase-B biological assaysFile in questo prodotto:
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