In this work, we report the results of a combined Monte Carlo (MC) and molecular dynamics (MD) approach applied to the conformational study of natural potent mitosis inhibitor Dolastatin 15. A GRID and CLogP analysis has been performed with the aim to provide some hints to the interpretation of the different behavior of Dolastatin 15 and Dolastatin 10, which has been examined in a former study

Conformational behavior of antineoplastic peptides dolastatin 10 and dolastatin 15 from Monte Carlo and molecular dynamics simulations molecular dynamics simulations

ORTUSO F;ALCARO S
2007-01-01

Abstract

In this work, we report the results of a combined Monte Carlo (MC) and molecular dynamics (MD) approach applied to the conformational study of natural potent mitosis inhibitor Dolastatin 15. A GRID and CLogP analysis has been performed with the aim to provide some hints to the interpretation of the different behavior of Dolastatin 15 and Dolastatin 10, which has been examined in a former study
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.12317/1468
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